By Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick
This quantity bargains a finished consultant at the thought and perform of amorphous strong dispersions (ASD) for dealing with demanding situations linked to poorly soluble medicinal drugs. In twenty-three inclusive chapters, the booklet examines thermodynamics and kinetics of the amorphous country and amorphous strong dispersions, ASD applied sciences, excipients for stabilizing amorphous strong dispersions resembling polymers, and ASD production applied sciences, together with spray drying, scorching soften extrusion, fluid mattress layering and solvent-controlled micro-precipitation know-how (MBP). every one expertise is illustrated by way of particular case reviews. moreover, devoted sections hide analytical instruments and applied sciences for characterization of amorphous strong dispersions, the prediction of long term balance, and the improvement of appropriate dissolution tools and regulatory elements. The publication additionally highlights destiny applied sciences at the horizon, equivalent to supercritical fluid processing, mesoporous silica, KinetiSol®, and using non-salt-forming natural acids and amino acids for the stabilization of amorphous systems.
Amorphous strong Dispersions: concept and perform is a helpful connection with pharmaceutical scientists drawn to constructing bioavailable and therapeutically potent formulations of poorly soluble molecules on the way to develop those applied sciences and enhance higher medicinal drugs for the future.
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